Louise McMillan will earn a 50th international cap this weekend as Scotland return to Hive Stadium to face France, with head coach Bryan Easson making two changes to the starting team.
Sarah Bonar has been ruled out of the championship with a shoulder injury, while Lana Skeldon will also miss the weekend's match with France with a knee problem.
While Bonar needs surgery on her AC joint, Easson was hopeful of having Skeldon back before the end of the Six Nations.
He said: "It wasn’t as bad as first expected. [She] had a scan on Monday and it was nothing really serious.
"She certainly misses this game and we are still waiting to see exactly what it is for England, but if we can get Lana for a couple of games that would be a real bonus.
"We do expect to see her back."
Leicester Tigers' Elis Martin is Skeldon's replacement and Easson has backed her to make an impact on her first Scotland start.
The Scotland head coach said: "She has worked really hard on her throwing that is the bedrock for any hooker.
"The ability to throw to the front, the middle and the tail is now really good with consistency while last week when she came on I thought she was really good around the pitch and she carried hard and defended well. She is growing all the time."
The head coach also praised McMillan, who won her first cap against Spain in 2016, ahead of her milestone appearance alongside Emma Wassell in Scotland's engine room.
He said: "What a journey she has been on. I cannot speak highly enough of her.
"She has grown a lot since she has been down at Saracens and she really deserves this occasion this weekend.
"I am delighted for her that she is starting as she has been such a stalwart part of this group."
Easson has named an unchanged backline from last weekend’s historic win in Wales, so Caity Mattinson and Helen Nelson retain their half-back partnership, with Lisa Thomson and Emma Orr continuing in the midfield.
Having both been nominated for Try of the Round for their efforts against Wales, wingers Coreen Grant and Rhona Lloyd will once again line up with Meryl Smith at fullback.
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Among the replacements, teenage centre Nicole Flynn and second row Fi McIntosh are in contention to win their first caps.
Easson praised 18-year-old Flynn, who impressed for Edinburgh during the Celtic Challenge.
He said: "She is unbelievable.
"She is just getting on with it and it looks like just another game to her, we are putting no pressure on her and we are excited to have her involved."
Molly Wright switches from prop cover to the back-up hooker, allowing Lisa Cockburn to come into the side as the replacement loosehead option.
Scotland: Meryl Smith, Rhona Lloyd, Emma Orr, Lisa Thomson, Coreen Grant, Helen Nelson, Caity Mattinson; Leah Bartlett, Elis Martin, Christine Belisle, Emma Wassell, Louise McMillan, Rachel Malcolm (Captain), Alex Stewart, Evie Gallagher
Replacements: Molly Wright, Lisa Cockburn, Elliann Clarke, Fiona McIntosh, Eva Donaldson, Mairi McDonald, Nicole Flynn, Chloe Rollie
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